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Basiliximab

    Brands

    DEA Class; Rx

    Common Brand Names; Simulect

    • Immunouppressants; 
    • Monoclonal Antibodies

    Immunosuppressant; chimeric (murine/human) monoclonal antibody (IgG); binds to and blocks the interleukin-2 receptor alpha chain (CD25); has not been associated with an increased risk of lymphoma or other malignancies.

    Indicated for acute kidney transplant rejection prophylaxis when used as part of an immunosuppressive regimen that includes cyclosporine and corticosteroids.

    For acute liver transplant rejection prophylaxis when used as part of an immunosuppressive regimen that includes cyclosporine and corticosteroids.

    Hypersensitivity

    —

    Development of human antimurine antibodies reported for murine products

    Risk of developing lymphoproliferative disorders may increase with immunosuppressive therapy

    Immunosuppressive therapy may increase risk of opportunistic infection

    Pregnancy Category: B

    Lactation: Unknown whether excreted in milk; because of the potential for adverse reactions, a decision should be made to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother

    Adults

    20 mg IV as a single dose.

    Elderly

    20 mg IV as a single dose.

    Adolescents

    >= 35 kg: 20 mg IV as a single dose.
    < 35 kg: 10 mg IV as a single dose.

    Children

    >= 35 kg: 20 mg IV as a single dose.
    < 35 kg: 10 mg IV as a single dose.

    Basiliximab

    powder for injection

    • 10mg
    • 20mg