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Aspirin/Chlorpheniramine/Dextromethorphan

    DEA Class;  OTC

    Common Brand Names; Alka-Seltzer Plus Flu

    Temporary Relief of Common Cold Cough & Upper Respiratory Symptoms

    Indicated for temporary relief of common Cold, cough and upper respiratory track infection.

    Hypersensitivity

    Liver damage

    Hypoprothrombinemia

    Vitamin K deficiency

    Bleeding disorders

    Asthma

    Due to association of aspirin with Reye syndrome, do not use in children (<16 years) with viral infections

    Narrow-angle glaucoma

    Symptomatic prostate hypertrophy

    Bladder-neck obstruction

    Stenosing peptic ulcer

    Agitation

    Agranulocytosis

    Anorexia

    Cerebral edema

    Coma

    Confusion

    Depression

    Dizziness

    Dyspepsia

    Dysrhythmias

    Euphoria

    Fatigue

    GI bleeding

    Headache

    Hemolytic anemia

    Hives

    Hypotension

    Insomnia

    Irritability

    Lethargy

    Aspirin may cause transient decrease in renal function and aggravate chronic kidney disease; avoid use in patients with severe anemia, with history of blood coagulation defects, or taking anticoagulants

    Dextromethorphan: do not take for persistent or chronic cough associated with smoking, asthma, or emphysema, or if it is accompanied by excessive phlegm unless directed by a healthcare provider; may slow respiration rate

    Chlorpheniramine: may cause significant confusional symptoms; not for administration to premature or full-term neonates

    Pregnancy category: D; avoid during pregnancy, particularly in third trimester because of risk for premature closure of the ductus arteriosus

    Lactation: Excreted in breast milk; do not breast feed

    Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

    Adults

    Alka-Seltzer Plus Flu: 2 tablets fully dissolved in 4 oz of water q6hr; not to exceed 8 tablets/day

    Pediatric 

    <12 years: Ask a pediatrician

    >12 years: 2 tablets fully dissolved in 4 oz of water q6hr; not to exceed 8 tablets/day

    Tablet, effervescent

    500mg/2mg/15mg