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Ascorbyl Palmitate

    Synonyms: L-Ascorbic acid 6-palmitate; ascorbylis palmitas; E304; 3-oxo Lgulofuranolactone 6-palmitate; vitamin C palmitate.

    Description: Ascorbyl palmitate is a practically odorless, white to yellowish powder.

    Chemical Name: L-Ascorbic acid 6-hexadecanoate

    • Ascorbyl palmitate is primarily used either alone or in combination with alpha tocopherol as a stabilizer for oils in oral pharmaceutical formulations and food products; generally 0.05% w/v is used.
    • It may also be used in oral and topical preparations as an antioxidant for drugs unstable to oxygen.
    • The combination of ascorbyl palmitate with alpha tocopherol shows marked synergism, which increases the effect of the components and allows the amount used to be reduced.
    • The solubility of ascorbyl palmitate in alcohol permits it to be used in nonaqueous and aqueous systems and emulsions

    Incompatibilities are known with oxidizing agents; e.g. in solution oxidation is catalyzed by trace metal ions such as Cu2 and Fe3

    Ascorbyl palmitate is used in oral pharmaceutical formulations and food products, and is generally regarded as an essentially nontoxic and nonirritant material. The WHO has set an estimated acceptable daily intake for ascorbyl palmitate at up to 1.25 mg/kg bodyweight

    Observe normal precautions appropriate to the circumstances and quantity of material handled. Ascorbyl palmitate dust may cause irritation to the eyes and respiratory tract. Eye protection is recommended.