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Amoxapine

    Brands

    DEA Class;  Rx

    Common Brand Names; Asendin

    • Antidepressants, TCAs

    Norepinephrine reuptake inhibitor with dopamine antagonist properties
    Used for the treatment of major depression in adults, including depression with psychotic features, concurrent anxiety, or agitation
    Requires close monitoring in pediatrics and young adults due to increased risk of suicidality during the initial stages of treatment

    Indicated for the treatment of major depression.

    Hypersensitivity

    Severe cardiovascular d/o

    Uncorrected narrow angle glaucoma

    Within 14 day of MAOIs (risk of serotonin syndrome); if linezolid or IV methylene blue (MAOIs) must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity; may resume 24 hr after last linezolid or methylene blue dose, or after 2 weeks of monitoring, whichever comes first

    Any drugs or conditions that prolong QT interval

    Acute recovery post-MI

    • Constipation (12-14%)
    • Dry mouth (12-14%)
    • Sedation (12-14%)
    • Anxiety
    • Ataxia
    • Blurred vision
    • Confusion
    • Dizziness
    • Edema
    • Headache
    • Fatigue
    • Nausea
    • Nervousness/restlessness
    • Prolactin levels increased
    • Rash
    • Sweating
    • Tremor
    • Weakness
    • Agranulocytosis
    • Diarrhea
    • ECG changes
    • EPS
    • Flatulence
    • Galactorrhea
    • Hypertension
    • Leukopenia
    • Menstrual irregularity
    • Mydriasis
    • Orthostatic hypotension
    • Seizure
    • Urinary retention
    • Urticaria
    • Vomiting
    • Tachycardia

    BPH, urinary/GI retention, incr IOP, hyperthyroidism, opne angle glaucoma, seizure d/o, brain tumor, respiratory impairment, hyperthyroidism

    Clinical worsening & suicide ideation may occur despite medication in adolescents & young adults (18-24 yo)

    Risk of anticholinergic side effects

    Possibility of tardive dyskinesia & NMS

    Pregnancy Category: C

    Lactation: enters breast milk; use with caution

    Adults

    400 mg/day PO outpatients; 600 mg/day PO inpatients.

    Geriatric

    300 mg/day PO, but lower doses (i.e., 150 mg/day PO) often adequate.

    Adolescents

    Safety and efficacy have not been established.

    Children

    Safety and efficacy have not been established.

    Infants

    Not indicated.

    Amoxapine

    tablet

    • 25mg
    • 50mg
    • 100mg
    • 150mg