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    DEA Class;  Rx

    Common Brand Names; Elavil, Levate

    • Antidepressants, TCAs

    Tertiary amine tricyclic antidepressant; amitriptyline is metabolized to nortriptyline, an active metabolite
    FDA-approved for use in adults for the treatment of depression; used off label for neuropathic pain and other uses
    Boxed warning for use in pediatric patients and young adults due to risk for suicidality

    Indicated for the treatment of major depression.

    For the treatment of social phobia (social anxiety disorder) or panic disorder.
    For the treatment of postherpetic neuralgia.
    For migraine prophylaxis.
    For the treatment of fibromyalgia.
    For the treatment of insomnia.
    For the treatment of persistent singultus (hiccups).
    For the treatment of primary nocturnal enuresis.
    For the adjunct treatment of bulimia nervosa.
    For the improvement of global symptoms of diarrhea-predominant irritable bowel syndrome.


    Acute recovery phase following MI

    Concurrent use with cisapride

    Contraindicated within 14 days of MAOIs; if linezolid or IV methylene blue (MAOIs) must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity; may resume 24 hr after last linezolid or methylene blue dose, or after 2 weeks of monitoring, whichever comes first

    • Extrapyramidal symptoms (EPS)
    • Fatigue
    • Hallucination
    • Headache
    • Hypertension
    • Increased LFTs
    • Insomnia
    • Lethargy
    • Leukopenia
    • MI
    • Nausea
    • Ocular pressure increased
    • Orthostatic hypotension
    • Palpitation
    • Paresthesia
    • Photosensitivity
    • Rash
    • Restlessness

    Bone marrow suppression reported

    Avoid use in narrow-angle glaucoma

    May cause sedation and impair mental and physical abilities

    Avoid use with any drugs or conditions that prolong QT interval

    May cause orthostatic hypotension

    Use caution in patients with cardiovascular disease, diabetes, mania, hepatic and renal impairment, thyroid dysfunction, and seizure disorder

    May worsen mania symptoms or precipitate mania in patients with bipolar disorder

    Clinical worsening and suicidal ideation may occur despite medication in adolescents and young adults (18-24 years)

    Risk of anticholinergic side effects; may cause constipation, urinary retention, blurred vision, and xerostomia

    Use caution in patients with urinary retention, open-angle glaucoma, BPH, decreased gastrointestinal motility, or paralytic ileus

    Possibility of EPS and neuroleptic malignant syndrome

    Abrupt discontinuation of therapy not recommended in patients receiving high doses for prolonged periods

    Fractures reported with therapy

    Pregnancy category: C

    Lactation: Distributed in breast milk; do not nurse (AAP states effect on nursing infants is unknown but may be of concern)


    150 mg/day PO in outpatients; 300 mg/day PO for hospitalized patients.


    150 mg/day PO in outpatients.


    150 mg/day PO in outpatients.


    < 12 years: Safety and efficacy have not been established.

    Amitriptyline hydrochloride


    • 10mg
    • 25mg
    • 50mg
    • 75mg
    • 100mg
    • 150mg