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Amitriptyline/​Perphenazine

    Brands

    DEA Class;  Rx

    Common Brand Names; Etrafon, Etrafon-A, Triavil

    • Psychotherapeutic Combos
    Oral combination phenothiazine antipsychotic and tricyclic antidepressant
    Used for schizophrenia and for moderate to severe anxiety/agitation and associated depressive symptoms
    Boxed warning for increased risk of suicidality in children, adolescents, and young adults during early treatment phase and increased mortality risk in elderly patients with dementia-related psychosis
    For the treatment of depression in patients with moderate to severe anxiety and/or agitation.
    For the treatment of schizophrenia in patients who have associated depressive symptoms.

    Tricyclic Antidepressant (amitriptyline): hypersensitivity, severe cardiovascular disorder, narrow angle glaucoma, within 14 days of MAOIs (risk of serotonin syndrome), any drugs or conditions that prolong QT interval, acute recovery post-MI

    Antipsychotic (perphenazine): hypersensitivity, CNS depression, neuroleptic malignant syndrome, poorly controlled seizure disorder, subcortical braine damage, coma, severe obtundation, high dose CNS depressants, blood dyscrasia, myelosuppression, liver damage

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    Pregnancy Category: D

    Lactation: excreted in breast milk; not recommended

    Adults

    The usual maximum is 16 mg/day PO perphenazine and 200 mg/day PO amitriptyline.

    Geriatric

    16 mg/day PO perphenazine and 200 mg/day PO amitriptyline.

    Adolescents

    Safety and efficacy have not been established.

    Children

    Safety and efficacy have not been established.

    Amitriptyline hydrochloride/perphenazine

    tablet

    • 10mg/2mg
    • 25mg/2mg
    • 10mg/4mg
    • 25mg/4mg
    • 50mg/4mg