Aluminum Phosphate Adjuvant

Synonyms: Adju-Phos; aluminum hydroxyphosphate; aluminium hydroxyphosphate; Rehydraphos.

Description: Aluminum phosphate adjuvant is a white hydrogel that sediments slowly and forms a clear supernatant

Chemical Name: Aluminum phosphate

Adsorbent; vaccine adjuvant.

• Aluminum phosphate adjuvant is used in parenteral human and veterinary vaccines.
• It activates Th2 immune responses, including IgG and IgE antibody responses.

The point of zero charge is related directly to the Al : P atomic ratio. Therefore, the substitution of additional phosphate groups for hydroxyl groups will lower the point of zero charge. Substitution of carbonate, sulfate, or borate ions for hydroxyl groups will also lower the point of zero charge.

Aluminum phosphate adjuvant is intended for use in parenteral vaccines and is generally regarded as safe. It may cause mild irritation, dryness, and dermatitis on skin contact. It may also cause redness, conjunctivitis, and short-term mild irritation on eye contact. Ingestion of large amounts of aluminum phosphate
adjuvant may cause respiratory irritation with nausea, vomiting, and constipation. Inhalation is unlikely, although the dried product may cause respiratory irritation and cough. Type I hypersensitivity reactions following parenteral administration have also been reported.

Observe normal precautions appropriate to the circumstances and quantity of material handled. Eye protection and gloves are recommended.

Aluminum hydroxide adjuvant.