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Aluminum Hydroxide/Magnesium Hydroxide/Simethicone

    DEA Class; OTC

    Common Brand Names; Mylanta, Mygel, DiGel, Gelusil, Rulox

    • Antacids, Combos

    Aluminum hydroxide: Neutralizes stomach hydrochloride to form AlCl3 salt plus water; increases gastric pH

    Magnesium hydroxide: Promotes bowel evacuation by causing osmotic retention of fluid, which causes the colon to distend with increased peristaltic activity; forms magnesium chloride when reacts with hydrochloric acid

    Simethicone: Disperses and prevents gas pockets in the GI system by decreasing surface tension of gas bubbles

    Indicated for Dyspepsia, Abdominal Bloating

    Hypersensitivity to any component of the formulation

    Aluminum hydroxide

    • Chalky taste

    • Constipation

    • Fecal impaction

    • Stomach cramps

    • Nausea

    • Vomiting

    • Rebound hyperacidity

    • Aluminum intoxication

    • Hypophosphatemia

    • Milk-alkali syndrome

    • Osteomalacia

    Magnesium hydroxide

    • Diarrhea

    • Hypermagnesemia


    • Loose stools

    Caution in renal failure

    May increase or decrease rate &/or degree of absorption of concomitantly administered oral drugs by changing GI transit time or by binding the drug

    Mg-restricted diet

    Similar Trade Names may have different compositions

    Do not use combination product for hyperphosphatemia

    Pregnancy Category: C

    Lactation: excretion in milk unknown

    10-20 mL PO q4-6hr taken 1 hour before or 3 hours after meals, OR

    Chew 2-4 tablets q4-6hr; not to exceed 12 tablets/24 hr

    Aluminum hydroxide/magnesium hydroxide/simethicone


    • (200mg/200mg/20mg)/5mL
    • (400mg/400mg/40mg)/5mL


    • (225mg/200mg/25mg)/5mL

    tablet, chewable

    • 200mg/200mg/25mg (Gelusil)