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Aluminum Hydroxide Adjuvant

    Synonyms: Alhydrogel; aluminii hydroxidum hydricum ad adsorptionem; aluminium hydroxide adjuvant; aluminium oxyhydroxide; poorly crystalline boehmite; pseudoboehmite; Rehydragel

    Description: Aluminum hydroxide adjuvant is a white hydrogel that sediments slowly and forms a clear supernatant

    Chemical Name: Aluminum oxyhydroxide

    Adsorbent; vaccine adjuvant.

    • Aluminum hydroxide adjuvant is used in parenteral human and veterinary vaccines.
    • It activates Th2 immune responses, including IgG and IgE antibody responses. It is also used for the isolation of certain serum components such as blood clotting factors.

    When exposed to phosphate, carbonate, sulfate, or borate anions, the point of zero charge for aluminum hydroxide adjuvant decreases.

    Aluminum hydroxide adjuvant is intended for use in parenteral vaccines and is generally regarded as nontoxic. It may cause mild irritation, dryness, and dermatitis on skin contact. On eye contact, aluminum hydroxide adjuvant may also cause redness, conjunctivitis, and short-term mild irritation. Ingestion of large amounts may cause gastrointestinal irritation with nausea, vomiting, and constipation. Inhalation of the dried product may cause respiratory irritation and cough. Type I hypersensitivity reactions following parenteral administration have been reported.

    Observe normal precautions appropriate to the circumstances and quantity of material handled. Eye protection and gloves are recommended

    Aluminum phosphate adjuvant.