Almotriptan

DEA Class; Rx

Common Brand Names; Axert

• Serotonin 5-HT-Receptor Agonists; 
• Antimigraine Agents

Hypersensitivity, severe hepatic or renal impairment, migraine prophylaxis

Ischemic heart disease, coronary artery vasospasm, including Prinzmetal’s variant angina, uncontrolled HTN, hemiplegic or basilar migraines, cluster HA, cerebrovascular syndromes, PVD

Do not use within 24 hr of another 5-HT1 agonist or ergot derivative, or within 2 weeks of MAOIs

Ergotamine-containing and ergot-type medications

Concomitant Use With 5-HT1 Agonists (eg, Triptans)

• Somnolence (1-5%)
• Dizziness (3-4%)
• Nausea (1-3%)
• Vomiting (2%)
• Dry mouth (1-2%)
• Headache (1-2%)
• Nausea (1-2%)
• Paresthesia (1-2%)
• Paresthesia (1%)
• Somnolence (>1%)

Transient and permanent blindness and partial vision loss have been reported with 5-HT-1 agonists

Use caution when prescribing to patient with known hypersensitivity to sulfonamides due to sulfonyl group in chemical structure of drug; sulfonyl group is structurally different from a sulfonamide; cross-sensitivity to almotriptan not systematically evaluated

Administer with caution to patients with diseases that may alter absorption, metabolism, or excretion of drugs, such as those with impaired hepatic or renal function

Pregnancy Category: C

Lactation: excretion in milk unknown; use with caution

Almotriptan malate

tablet

• 6.25mg
• 12.5mg