General Description
Synonyms
ATEC; Citroflex A-2; triethyl acetylcitrate; triethyl O-acetylcitrate; triethyl citrate acetate.
Description
Acetyltriethyl citrate occurs as a clear, odorless, practically colorless oily liquid.
Chemical Name: 1,2,3-Propanetricarboxylic acid, 2-acetyloxy, triethyl ester
Uses
- Acetyltriethyl citrate is used to plasticize polymers in formulated pharmaceutical coatings.
- The coating applications include capsules, tablets, beads and granules for taste masking, immediate release, sustained-release and enteric formulations.
- It is also used in diffusion-controlled release drug delivery systems.
Incompatibilities
Acetyltriethyl citrate is incompatible with strong alkalis and oxidizing materials.
Safety
Acetyltriethyl citrate is used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritating material. However, ingestion of large quantities may be harmful.
Handling Precautions
Observe normal precautions appropriate to the circumstances and quantity of material handled. Acetyltriethyl citrate may be irritating to the eyes or the respiratory system as a mist or at elevated temperatures. Gloves and eye protection are recommended for
normal handling.
Related Substances
Acetyltributyl citrate; tributyl citrate; triethyl citrate.