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Paracetamol/Caffeine/Isometheptene

    Brands

    DEA Class;  Rx

    Common Brand Names; Prodrin

    Analgesics, Other combo

    Acetaminophen: Nonnarcotic analgesic; reduces the perception of pain impulses originating from dilated cerebral vessels

    Caffeine: Cranial vasoconstrictor; enhances vasoconstrictor effect of isometheptene; also used as a central stimulant for relief of headache

    Isometheptene: Sympathomimetic amine that acts by constricting dilated cranial and cerebral arterioles, thus reducing the stimuli that lead to vascular headaches

    Indicated in Migraine Headache, Tension Headache

    Glaucoma

    Severe renal disease

    Severe hypertension

    Organic heart disease

    Severe hepatic disease

    Coadministration or within 2 weeks of MAOIs

    Rash

    Transient dizziness

    Cautions with history of hypertension, peripheral vascular disease, and after recent cardiovascular events

    Pregnancy Category: C Lactation: Unknown if distributed in human breast milk

    Adults

    1 or 2 tablets PO at onset of headache, then 1 tablet hourly until relieved; not to exceed 5 tablets/12 hr

    Pediatric

    Safety and efficacy not established

    acetaminophen/caffeine/isometheptene

    tablet

    • 325mg/20mg/65mg