Triolein

Synonyms: Captex GTO; glycerol trielaidate; glyceryl trioleate; 9-octadecenoic acid-1,2,3-propanetriyl ester; olein; 1,2,3-propanetriyl tris((E)-9- octadecenoate); trielaidin; trielaidoylglycerol; 1,2,3-tri(cis-9-octadecenoyl)glycerol.

Description: Triolein occurs as a clear, colorless to yellowish oily liquid, and is tasteless and odorless.

Chemical Name: 2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl (Z)-octadec-9-enoate

Emollient; penetration enhancer; solubilizing agent; solvent.

• Triolein is used as a solubilizer and solvent in injectable preparations.

• It has been used in marketed preparations of sustained-release injections of cytarabine and multivesicular liposomal injections of morphine sulfate.

• It has also been used in enteric coatings for oral preparations in combination with other enteric coating excipients to protect against degradation by pancreatic lipase.

• Triolen is used in personal care products as a skin-conditioning and viscosity-controlling agent.

Triolein is incompatible with strong oxidizing agents and spontaneously flammable products. Being a triglyceride ester, triolein can be hydrolyzed by strong acids, and particularly by strong bases. It is possible for primary amines to form an adduct across the olefinic double bonds (analogous to a Michael addition).

Triolein is used in injectable preparations, in enteric coatings for oral preparations, and in personal care products. Chronic exposure may cause nausea and vomiting, and higher exposures may cause unconsciousness.

Observe normal precautions appropriate to the circumstances and quantity of the material handled. Use of a mask and/or respirator is recommended in case aerosol/dust is formed. Ventilation is recommended to control dust or fumes from the material. For eye protection, safety glasses with side shields are recommended. For hand protection, PVC or other plastic material gloves are recommended.

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