Sulfobutylether β-Cyclodextrin

Synonyms: b-Cyclodextrin sulfobutylether, sodium salt; Captisol; (SBE)m-betaCD; SBE7-b-CD; SBECD; sulfobutylether-b-cyclodextrin, sodium salt

Description:

b-Cyclodextrin is a cyclic oligosaccharide containing seven D-(þ)- glucopyranose units attached by a glucoside bonds (see Cyclodextrins). Sulfobutylether b-cyclodextrin is an anionic bcyclodextrin derivative with a sodium sulfonate salt separated from the hydrophobic cavity by a butyl spacer group. The substituent is introduced at positions 2, 3, and 6 in at least one of the glucopyranose units in the cyclodextrin structure. Introducing the sulfobutylether (SBE) into b-cyclodextrin can produce materials with different degrees of substitution, theoretically from 1 to 21; the hepta-substituted preparation (SBE7-b-CD) is the cyclodextrin with the most desirable drug carrier properties

Chemical Name: β-Cyclodextrin sulfobutylether, sodium salt

Biocompatibility enhancer; complexing agent; dissolution enhancer; osmotic agent; solubilizing agent; stabilizing agent; tablet and capsule diluent; viscosity-increasing agent; water activity reducing agent.

• Cyclodextrins are crystalline, nonhygroscopic, cyclic oligosaccharides derived from starch (see Cyclodextrins).

• Sulfobutylether bcyclodextrin is an amorphous, anionic substituted b-cyclodextrin derivative other substituted cyclodextrin derivatives are also available.

• Sulfobutylether b-cyclodextrin can form noncovalent complexes with many types of compounds including small organic molecules, peptides, and proteins.

• It can also enhance their solubility and stability in water.

• The first application of sulfobutylether bcyclodextrin was in injectable preparations; it can also be used in oral solid and liquid dosage forms, and ophthalmic, inhalation, and intranasal formulations.

• Sulfobutylether bcyclodextrin can function as an osmotic agent and/or a solubilizer for controlled-release delivery and has antimicrobial preservative properties when present at sufficient concentrations.

The preservative activity of benzalkonium chloride is reduced in the presence of sulfobutylether b-cyclodextrin

Confectioner’s sugar is used in confectionery and oral pharmaceutical formulations. It is generally regarded as a relatively nontoxic and nonirritant material. See also Sucrose.

Observe normal precautions appropriate to the circumstances and quantity of material handled.

a-Cyclodextrin; b-cyclodextrin; g-cyclodextrin; dimethyl-b-cyclodextrin; 2-hydroxyethyl-b-cyclodextrin; hydroxypropyl betadex; 3- hydroxypropyl-b-cyclodextrin; trimethyl-b-cyclodextrin