General Description
Synonyms: Acetic acid, ethylene ester polymer with ethane; CoTran; ethylene/ vinyl acetate copolymer; EVA; EVA copolymer; EVM; poly(ethylene-co-vinyl acetate); VA/ethylene copolymer; vinyl acetate/ethylene copolymer.
Description: Ethylene vinyl acetate is available as white waxy solids in pellet or powder form. Films are translucent
Chemical Name: Ethylene vinyl acetate copolymer
Functions
Transdermal delivery component.
Uses
Ethylene vinyl acetate copolymers are used as membranes and backings in laminated transdermal drug delivery systems.
They can also be incorporated as components in backings in transdermal systems.
Ethylene vinyl acetate copolymers have been shown to be an effective matrix and membrane for the controlled delivery of atenolol triprolidine and furosemide.
The system for the controlled release of atenolol can be further developed using ethylene vinyl acetate copolymers and plasticizers.
Incompatibilities
Ethylene vinyl acetate is incompatible with strong oxidizing agents and bases.
Safety
Ethylene vinyl acetate is mainly used in topical pharmaceutical applications as a membrane or film backing. Generally it is regarded as a relatively nontoxic and nonirritant excipient.
Handling Precautions
Observe normal precautions appropriate to the circumstances and quantity of material handled. Ethylene vinyl acetate powder may form an explosive mixture with air.