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Melarsoprol

    Brands

    DEA Class; Rx

    Common Brand Names; Arsobal

    • Antiprotozoal Agents

    Inhibits synthesis of ATP – the energy required for survival of the parasite

    Indicated for the African Trypanosomiasis (Sleeping Sickness)

    Glucose-6-phosphate dehydrogenase (G6PD) deficiency, hypersensitivity

    • Hypertension
    • Myocardial damage
    • Encephalopathy
    • Peripheral neuropathy
    • Colic
    • Vomiting
    • Albuminuria
    • Herxheimer-type reaction

    —

    Pregnancy Category: no studies conducted

    Lactation: not known if excreted in breast milk

    Not commercially available in US; however, available as treatment IND from CDC; 800-CDC-INFO (800-232-4636)

    2-3.6 mg/kg/day IV x3 days  

    After 1 week: 3.6 mg/kg/day IV x3 days

    Repeat again after 10-21 days: 3.6 mg/kg/day

    Melarsoprol