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Brompheniramine/Dextromethorphan/Pseudoephedrine

    Brands

    DEA Class; OTC, Rx

    Common Brand Names; Bromfed-DM

    • Cough/Cold, Non-narcotic Combos; 
    • Antihistamine/Antitussive/Decongestant Combos

    Oral combination of an antihistamine, nasal decongestant, and antitussive
    Used for the treatment of cough and upper respiratory symptoms due to seasonal allergic rhinitis or the common cold
    May cause increased blood pressure and/or sedation; excitability may occur, especially in children

    Indicated for the treatment of cough and upper respiratory symptoms due to seasonal allergic rhinitis or the common cold, including sneezing, rhinorrhea, itching of the nose and throat, nasal congestion, and itchy, watery eyes.

    • Hypersensitivity
    • Acute asthma attack
    • Severe hypertension
    • Coronary artery disease
    • Narrow-angle glaucoma
    • Symptomatic prostate hypertrophy
    • Bladder-neck obstruction
    • Stenosing peptic ulcer
    • Dizziness
    • Drowsiness
    • Dry mouth, throat, and nose
    • Thickening of mucus in nose or throat
    • GI disturbances
    • Arrhythmia
    • Palpitations
    • Convulsion
    • Excitability
    • Tremor
    • Weakness

    Brompheniramine: May cause significant confusional symptoms; not for administration to premature or full-term neonates

    Dextromethorphan: Do not take for persistent or chronic cough associated with smoking, asthma, or emphysema, or if it is accompanied by excessive phlegm unless directed by a healthcare provider; may decrease respiration rate

    Pseudoephedrine: Caution in cardiovascular disease, diabetes mellitus, prostatic hypertrophy and increased intraocular pressure

    Pregnancy category: C

    Lactation: excreted in breast milk/not recommended

    Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

    Adults

    24 mg/day PO brompheniramine; 360 mg/day PO pseudoephedrine; 120 mg/day PO dextromethorphan.

    Geriatric

    24 mg/day PO brompheniramine; 360 mg/day PO pseudoephedrine; 120 mg/day PO dextromethorphan.

    Adolescents

    24 mg/day PO brompheniramine; 360 mg/day PO pseudoephedrine; 120 mg/day PO dextromethorphan.

    Children

    12 years: 24 mg/day PO brompheniramine; 360 mg/day PO pseudoephedrine; 120 mg/day PO dextromethorphan.
    6 to 11 years: 12 mg/day PO brompheniramine; 180 mg/day PO pseudoephedrine; 60 mg/day PO dextromethorphan.
    2 to 5 years: 6 mg/day PO brompheniramine; 90 mg/day PO pseudoephedrine; 30 mg/day PO dextromethorphan.
    1 year: Safety and efficacy have not been established.

    Infants

    Safety and efficacy have not been established.

    Neonates

    Safety and efficacy have not been established.

    Brompheniramine/dextromethorphan/pseudoephedrine

    oral syrup

    • (2 mg/10mg/30mg)/5mL (Bromfed DM)
    • (3 mg/30mg/50mg)/5mL (Bromdex D)

    oral elixir

    • (1 mg/5mg/15mg)/5mL (Bromaline DM)