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Aminosalicylic Acid

    Brands

    DEA Class; Rx

    Common Brand Names; Paser

    • 5-Aminosalicylic Acid Derivatives; 
    • Antitubercular Agents

    Oral antituberculosis agent that may inhibit folic acid synthesis and/or inhibit synthesis of a cell wall component 
    Use second-line to treat tuberculosis infection; often used for multi-drug resistant tuberculosis
    Must be used as part of a multi-drug treatment regimen

    Indicated for treatment of TB in combination with other active agents; most commonly used in regimens for multi-drug resistant TB or when intolerance to other antitubercular agents occurs

    Treatment of mild-to-moderate ulcerative colitis in patients intolerant to sulfasalazine

    Hypersensitivity

    End-stage renal disease

    GI intolerance manifested by nausea, vomiting, diarrhea, and abdominal pain

    Hypersensitivity reactions: Fever, skin eruptions of various types, including exfoliative dermatitis, infectious mononucleosis-like, or lymphoma-like syndrome, leucopenia, agranulocytosis, thrombocytopenia, Coombs’ positive hemolytic anemia, jaundice, hepatitis, pericarditis, hypoglycemia, optic neuritis, encephalopathy, Leoffler’s syndrome, vasculitis and a reduction in prothrombin

    Crystalluria (prevent by maintaining urine at neutral or alkaline pH)

    Monitor liver function; reports of drug-induced hepatitis with rapidly absorbed aminosalicylic acid preparations

    Pregnancy Category: C

    Lactation: Distributed in human breast milk; caution advised

    Adults

    12 g/day PO.

    Geriatric

    12 g/day PO.

    Adolescents

    300 mg/kg/day (Max: 12 g/day) PO.

    Children

    300 mg/kg/day (Max: 10 g/day) PO.

    Infants

    300 mg/kg/day PO.

    Neonates

    Safety and efficacy have not been established.

    Aminosalicylic acid

    oral granules, delayed-release

    • 4g/packet