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Nilutamide

    Brands

    DEA Class; Rx

    Common Brand Names; Nilandron

    • Antineoplastics, Antiandrogen

    Oral antiandrogen; used for metastatic prostate CA; similar in action to bicalutamide and flutamide; differs from steroidal antiandrogens (e.g., finasteride) in that nilutamide is specific for the androgen receptor.

    Indicated for the treatment of metastatic prostate cancer in combination with orchiectomy.
     
    For the treatment of prostate cancer.

    Hypersensitivity; severe hepatic, and/or respiratory impairment

    • Hot flushes (28%)
    • Testicular atrophy (16%)
    • Altered adaptation to dark (13%)
    • Dyspnea (11%)
    • Heachache (undefined)
    • Insomnia (undefined)
    • Abdominal pain (10%)
    • Nausea (10%)
    • Constipation
    • Diarrhea
    • Aplastic anemia
    • Leukopenia
    • Alcohol intolerance
    • Angina, heart failure
    • HTN
    • Syncope
    • Dizziness
    • Malaise
    • Elevated LFTs
    • Gynecomastia
    • Impaired vision
    • Interstitial pneumonitis
    • UTI

    Hepatic Impairment

    Hepatitis reported

    Delay in vision adaptation to dark

    Pregnancy Category: C

    Lactation: N/A

    Adults

    300 mg PO/day.

    Elderly

    300 mg PO/day.

    Adolescents

    Safety and efficacy have not been established.

    Children

    Safety and efficacy have not been established.

    Nilutamide

    tablet

    • 150mg