Atenolol/Chlorthalidone

DEA Class;  Rx

Common Brand Names; Tenoretic

No adverse effects specific to the combination have been observed; adverse effects limited to those previously reported with atenolol and chlorthalidone

Atenolol

• 2/3° AV block
• Bradycardia
• Cold extremities
• Diarrhea
• Drowsiness
• Hypotension
• Leg pain
• Lethargy
• Lightheadedness
• Nausea
• Postural hypotension
• Unusual dreams
• Vertigo

Chlorthalidone

• Blurred vision, xanthopsia
• Constipation
• Diarrhea
• Dizziness
• Electrolyte abnormalities
• Headache, vasculitis
• Hyperglycemia
• Hyperuricemia
• Hypotension
• Impotence
• Loss of appetite
• Muscular spasticity, restlessness
• Nausea/vomiting
• Paresthesia
• Photosensitivity, phototoxicity

Surgery/Anesthesia: Chronically administered beta-blockers should not be routinely withdrawn prior to major surgery; however, impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures

Bronchospastic disease

Cerebrovascular insufficiency

Correct hypokalemia before initiating therapy

CHF, beta blockade carries the potential hazard of further depressing myocardial contractility and precipitating more severe failure

Use caution in diabetes mellitus, fluid or electrolyte imbalance (hypochloremic alkalosis, hypercalcemia, hyponatremia), moderate or high cholesterol concentrations, history of asthma, hyperuricemia or gout, hypotension, SLE

Hyperthyroidism/thyrotoxicosis, liver disease

May aggravate digitalis toxicity

Peripheral vascular disease

Renal impairment

Risk of male sexual dysfunction

Sensitivity reactions may occur with or without history of allergy or asthma

Compromised left ventricular function

Patients receiving clonidine – discontinue atenolol several days prior to withdrawal of clonidine

Pregnancy Category: D

Lactation: excreted in breast milk, use caution

Atenolol/Chlorthalidone