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Alfuzosin

    Brands

    DEA Class;  Rx

    Common Brand Names; Alfutral, UroXatral, Xatral

    • BPH, Alpha Blockers

    Oral alpha-1 adrenergic blocker
    Used to treat benign prostatic hypertrophy (BPH) in adult males
    Similar to tamsulosin, alfuzosin appears to be more specific for alpha-1a receptors than other alpha-blockers

    Indicated for the symptomatic treatment of benign prostatic hyperplasia (BPH).
    For the treatment of erectile dysfunction (ED) in combination with sildenafil in patients with lower urinary tract symptoms (LUTS) suggestive of BPH.

    Hypersensitivity

    Moderate to severe liver impairment

    Coadministration with potent CYP3A4 inhibitors (eg, ketoconazole, itraconazole, ritonavir) or other alpha1-blocking agents

    • Abdominal pain (1-2%)
    • Back pain (1-2%)
    • Brochitis (1-2%)
    • Constipation (1-2%)
    • Dizziness (5.7%)
    • Dyspepsia (1-2%)
    • Fatigue (2.7%)
    • Headache (3%)
    • Impotence (1-2%)
    • Nausea (1-2%)
    • Pharyngitis (1-2%)
    • URT infection (3%)
    • Sinusitis (1-2%)
    • Upper respiratory infection (3%)
    • General disorders: Edema
    • Cardiac disorders: Tachycardia, chest pain, angina pectoris in patients with pre-existing coronary artery disease, atrial fibrillation
    • Gastrointestinal disorders: Diarrhea, vomiting
    • Hepatobiliary disorders: Hepatocellular and cholestatic liver injury (including cases with jaundice leading to drug discontinuation)
    • Upper respiratory system: Rhinitis
    • Reproductive system: Priapism
    • Dermatology: Rash, pruritus, urticaria, angioedema, toxic epidermal necrolysis
    • Vascular disorders: Flushing
    • Blood and lymphatic system disorders: Thrombocytopenia

    Caution in coronary artery disease, liver disease, symptomatic orthostatic hypotension or coadministration with other drugs that lower blood pressure

    May cause syncope (first-dose effect)

    Discontinue treatment if angina occurs or worsens

    Rule out prostate cancer before initiating therapy (symptoms similar)

    Priapism may occur with use

    Rule out prostate cancer prior to treatment

    Caution with renal impairment (ieg, CrCl <30 mL/min)

    Caution with history of prolonged QT syndrome (shown to prolong QT interval)

    Intraoperative floppy iris syndrome during cataract surgery reported Advise patient regarding risk of priapism

    Do not chew or crush tablets

    Not for use as antihypertensive drugDrug is not indicated for use in women; there are no adequate data on developmental risk associated with use in pregnant women

    Drug is not indicated for use in women; there are no adequate data on developmental risk associated with use in pregnant women

    Drug is not indicated for use in women; there are no data on presence in human milk, effect on breastfed child, or on milk production

    Adults

    10 mg/day PO.

    Geriatric

    10 mg/day PO.

    Adolescents

    Safety and efficacy have not been established.

    Children

    Safety and efficacy have not been established.

    Infants

    Not indicated.

    Alfuzosin hydrochloride

    tablet, extended release

    • 10mg