Skip to content

Echothiophate iodide

    Brands

    DEA Class;  Rx

    Common Brand Names; Phospholine Iodide

    • Miotics, Cholinesterase Inhibitors; 
    • Antiglaucoma, Miotics

    Ophthalmic cholinesterase-inhibitor miotic agent
    Used in adults to decrease intraocular pressure; used in pediatric patients to diagnose and treat concomitant esotropias with a significant accommodative component
    Contraindicated in patients with active uveal inflammation, angle-closure glaucoma without iridectomy, or a hypersensitivity to the drug

    For the treatment of increased intraocular pressure.

    For the diagnosis and treatment of strabismus of the accommodative esotropia type.

    For the treatment of accommodative strabismus.

    Hypersensitivity

    Active uveitis

    Angle-closure glaucoma without iridectomy

    Relative: history of retinal detachment; quiescent/history of uveitis

    Burning

    Bradycardia

    Flushing

    Hypotension

    Stinging

    Lacrimation

    Iris cyst formation

    Diarrhea

    Nausea

    Vomiting

    Blurred vision

    Ciliary redness

    Increased intraocular pressure

    Miosis

    Myopia

    Uveitis activation

    Lens opacities

    Retinal detachment

    Lid muscle twitching

    Use with caution, if at all, in patients with marked vagotonia, bronchial asthma, spastic gastrointestinal disturbances, peptic ulcer, pronounced bradycardia and hypotension, recent myocardial infarction, epilepsy, parkinsonism, and other disorders that may respond adversely to vagotonic effects

    Concomitant cholinergic drugs (succinylcholine, systemic myasthenia gravis drugs)

    Potential for conjunctival thickening, retinal detachment, lens opacity; use with caution, where there is prior history of retinal detachment

    Temporary discontinuance of medication necessary if cholinergic side-effects, including hyperhidrosis, sialorrhea, urinary incontinence, diarrhea, muscle weakness, cardiac irregularities, or respiratory difficulties occur

    Do not use more frequently than q12hr

    Few weeks of therapy may depress plasma and erythrocyte cholinesterase levels

    Pregnancy Category: C

    Lactation: Discontinue drug or do not nurse

    Adults

    2 drops/day per affected eye.

    Geriatric

    2 drops/day per affected eye.

    Adolescents

    1 drop/day per affected eye.

    Children

    1 drop/day per affected eye.

    Echothiophate iodide

    ophthalmic solution

    • 0.125%