Classes
DEA Class; Rx
Common Brand Names; Provocholine
- Diagnostic Agents, Other
Description
Orally inhaled cholinergic agonist
Used for diagnosis of bronchial airway hyperreactivity (methacholine challenge test) in patients 5 years of age and older who do not have clinically apparent asthma
May occasionally be false-positive after influenza or other upper respiratory infection; after vaccination; in very young or geriatric patients; in patients with chronic lung disease (CLD); in patients with allergic rhinitis with or without asthma symptoms; in tobacco smoking patients; or in patients after exposure to air pollutants
Indications
Used for bronchial airway hyperreactivity diagnosis in patients who do not have clinically apparent asthma.
For 2-minute tidal breathing dosing method.
Contraindications
Methacholine is contraindicated in patients with hypersensitivity to methacholine or other parasympathomimetic agents.
Adverse Effects
Bronchospasm, Wheezing, Throat irritation, Headache, Pruritus, Cough
Warnings
Acute bronchospasm, asthma
The methacholine challenge test may occasionally be false-positive after influenza or other upper respiratory infection; after vaccination; in very young (neonates, infants, children) or geriatric patients; in patients with chronic lung disease (CLD), such as cystic fibrosis, sarcoidosis, tuberculosis, or chronic obstructive pulmonary disease (COPD); in patients with allergic rhinitis with or without asthma symptoms; in tobacco smoking patients; or in patients after exposure to air pollutants.
Pregnancy and Lactation
Diagnosis of bronchial airway hyperreactivity with bronchoprovocation challenge is not recommended during pregnancy
There are no available data on the presence of methacholine in human milk, the effect on the breast-fed infant, or the effect on milk production.
Maximum Dosage
380 mcg oral inhalation as single dose and 758.516 mcg oral inhalation as cumulative dose per methacholine challenge test.
380 mcg oral inhalation as single dose and 758.516 mcg oral inhalation as cumulative dose per methacholine challenge test.
380 mcg oral inhalation as single dose and 758.516 mcg oral inhalation as cumulative dose per methacholine challenge test.
Children 5 to 12 years: 380 mcg oral inhalation as single dose and 758.516 mcg oral inhalation as cumulative dose per methacholine challenge test.
Children 1 to 4 years: Safety and efficacy have not been established.
Safety and efficacy have not been established.
Safety and efficacy have not been established.