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Paracetamol/Ibuprofen

    DEA Class;  OTC

    Common Brand Names; Advil Dual Action

    • Analgesics, Other Combos

    Acetaminophen

    Acts on hypothalamus to produce antipyresis

    May work peripherally to block pain impulse generation; may also inhibit prostaglandin synthesis in CNS

    Ibuprofen

    Elicits anti-inflammatory, analgesic, and antipyretic activity

    Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase (COX) isoenzymes, COX-1 and COX-2

    May inhibit chemotaxis, alter lymphocyte activity, decrease proinflammatory cytokine activity, and inhibit neutrophil aggregation; these effects may contribute to its anti-inflammatory activity

    Indicated for temporary relief of mild pain caused by headache, backache, muscular aches, toothache, menstrual cramps, minor pain of arthritis

    Ibuprofen

    • Hypersensitivity to ibuprofen, other NSAIDs, aspirin, or excipients

    • Perioperative pain in setting of CABG surgery

    Acetaminophen

    • Hypersensitivity

    • Severe active liver disease

    Acetaminophen hepatotoxicity possible in chronic alcoholics following various dose levels

    Severe or recurrent pain or high or continued fever may indicate a serious illness

    Ibuprofen

    If pregnant or breastfeeding, ask a health professional before use; it is especially important not to use ibuprofen at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor; it may cause problems in the unborn child or complications during delivery

    Keep out of reach of children; in case of overdose, get medical help or contact a poison control center right away; prompt medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms

    Pregnancy;

    Ask a health professional before use; it is especially important not to use ibuprofen at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery; NSAID use during third trimester increases risk of premature closure of the fetal ductus arteriosus

    Lacation:

    Ibuprofen

    Considered compatible with breastfeeding (LactMed)

    No lactation studies have been conducted; however, limited published literature reports that following oral administration, ibuprofen is present in human milk at relative infant doses of 0.06-0.6% of the maternal weight-adjusted daily dose

    Acetaminophen

    Considered compatible with breastfeeding (LactMed)

    Adults

    Acetaminophen containing products: Not to exceed a cumulative dose of 3.25 g/day of acetaminophen; under supervision of healthcare professional, daily doses of up to 4 g/day may be used

    Pediatric

    <12 years: Safety and efficacy not established

    ≥12 years: 2 tablets PO q8hr while symptoms persist; not to exceed 6 tablets/day, unless directed by physician

    acetaminophen/ibuprofen

    tablet

    • 250mg/125mg