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Paracetamol/Dextromethorphan

    Brands

    DEA Class;  OTC

    Common Brand Names; Children’s Triaminic Cough & Sore Throat Daytime, Children’s Tylenol Plus Cough & Sore Throat, Tylenol Cough & Sore Throat Daytime

    • Cough/Cold, Non-narcotic Combos

    Acetaminophen blocks pain impulse generation peripherally and may inhibit the generation of prostaglandin in the CNS. Reduces fever by inhibiting the hypothalamic heat-regulating center.

    Dextromethorphan is a cough suppressant that acts centrally on the cough center in the medulla.

    Indicated in Relief of Cold & Flu Symptoms

    Contraindicated in documented hypersensitivity; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer; known G-6-PD deficiency

    Acetaminophen hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose

    Do not take dextromethorphan for persistent or chronic cough associated with smoking, asthma, or emphysema, or if it is accompanied by excessive phlegm unless directed by a healthcare provider; dextromethorphan may slow the breathing

    Acetaminophen: Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash

    Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

    Adults

    30mL [(1000mg/30mg)/30mL] PO q6hr; not to exceed 120 mL/day

    Pediatric

    4 Years Old

    Not recommended

    4-6 Years Old

    5mL [(160mg/5mg)/5mL] PO q4hr; not to exceed 5 doses/day

    6-12 Years Old

    10mL [(160mg/5mg)/5mL] PO q4hr; not to exceed 5 doses/day

    >12 Years Old

    30mL [(1000mg/30mg)/30mL] PO q6hr; not to exceed 120mL/day

    acetaminophen/dextromethorphan

    liquid

    • (1000mg/30mg)/30mL
    • (160mg/5mg)/5mL