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Paracetamol/Chlorpheniramine

    Brands

    DEA Class;  OTC

    Common Brand Names; Coricidin HBP Cold & Flu, St. Joseph Cold & Flu

    Cough/Cold, Non-narcotic Combos; 

    Antihistamines, Alkylamine Derivatives

    Oral combination of an analgesic/antipyretic and antihistamine
    Used for the treatment of fever, headache, minor aches and pains, rhinorrhea, and sneezing
    May cause sedation; excitability may occur, especially in children

    For the treatment of headache, mild pain, rhinorrhea, or sneezing.
    For the treatment of fever.

    Contraindicated in documented hypersensitivity; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer; known G-6-PD deficiency

    Chlorpheniramine may cause significant confusional symptoms; not for administration to premature or full-term neonates

    Hypotension

    Palpitations

    Tachycardia

    Anxiety

    Confusion

    Depression

    Dizziness

    Drowsiness

    Euphoria

    Fatigue

    Headache

    Insomnia

    Irritability

    Nervousness

    Tremors

    Anorexia

    Constipation

    Diarrhea

    Nausea

    Vomiting

    Agranulocytosis

    Anemia

    Blood dyscrasias (neutropenia, pancytopenia, leukopenia, thrombocytopenia)

    Hemolytic anemia

    Bilirubin and alkaline phosphatase may increase

    Thickening of bronchial secretions

    Wheezing

    Dry mouth, nose, throat

    Acetaminophen hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose

    Acetaminophen: Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash

    Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

    Adults

    3,900 mg/day PO acetaminophen; 24 mg/day PO chlorpheniramine.

    Geriatric

    3,900 mg/day PO acetaminophen; 24 mg/day PO chlorpheniramine.

    Adolescents

    3,900 mg/day PO acetaminophen; 24 mg/day PO chlorpheniramine.

    Children

    12 years: 3,900 mg/day PO acetaminophen; 24 mg/day PO chlorpheniramine.
    6 to 11 years: 1,625 mg/day PO acetaminophen; 10 mg/day PO chlorpheniramine.
    1 to 5 years: Safety and efficacy have not been established.

    Infants

    Safety and efficacy have not been established.

    Neonates

    Safety and efficacy have not been established.

    acetaminophen/chlorpheniramine

    tablet

    • 325mg/2mg