Classes
DEA Class; Rx
Common Brand Names; Ethrane
- General Anesthetics, Systemic
Description
Enflurane is a halogenated inhalational anesthetic agent used for the induction and maintenance of anesthesia and for analgesia during labor and delivery.
Indications
Enflurane may be used for induction and maintenance of general anesthesia. Enflurane may be used to provide analgesia for vaginal delivery. Low concentrations of enflurane may also be used to supplement other general anesthetic agents during delivery by Cesarean section. Higher concentrations of enflurane may produce uterine relaxation and an increase in uterine bleeding.
Contraindications
Known sensitivity to Enflurane or other halogenated anesthetics.
Known or suspected genetic susceptibility to malignant hyperthermia.
Adverse Effects
- Malignant hyperthermia
- Motor activity exemplified by movements of various muscle groups and/or seizures may be encountered with deep levels of Enflurane anesthesia, or light levels with hypocapnia.
- Hypotension, respiratory depression, and hypoxia have been reported.
- Arrhythmias, shivering, nausea and vomiting have been reported.
- Elevation of the white blood count has been observed.
- Mild, moderate and severe liver injury, including hepatic failure, may rarely follow anesthesia with enflurane. Serum transaminases may be increased and histologic evidence of injury may be found. The histologic changes are neither unique nor consistent. In several of these cases, it has not been possible to exclude enflurane as the cause or as a contributing cause to liver injury. The incidence of unexplained hepatotoxicity following the administration of enflurane is unknown, but it appears to be rare and not dose related.
Pregnancy and Lactation
Pregnancy category: B
Lactation: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when enflurane is administered to a nursing woman.
How supplied
Carbamide Peroxide
Ear Drops
- 15ml